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Mar. Drugs 2015, 13(8), 4721-4732; doi:10.3390/md13084721

Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts

Department of Food and Life Science, Pukyong National University, Busan 608-737, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 15 June 2015 / Revised: 8 July 2015 / Accepted: 22 July 2015 / Published: 31 July 2015
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Abstract

In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular oxidative stress induced by UVA irradiation in skin fibroblasts. We found that porphyra-334 significantly reduced the secretion and expression of IL-6 and TNF-α, reduced nuclear expression of Nuclear factor-κB (NF-κB), and sustained NF-E2-related factor 2 (Nrf2) activation. Further mechanism research revealed that porphyra-334 promoted the Nrf2 signaling pathway in UVA-irradiated skin fibroblasts. Our results show that the antioxidant effect of porphyra-334 is due to the direct scavenging of oxidative stress and its inhibitory effects on NF-κB-dependent inflammatory genes, such as IL-6 and TNF-κ. Therefore, we hypothesize that boosting the Nrf2- NF-κB-dependent response to counteract environmental stress is a promising strategy for the prevention of UVA-related damage. View Full-Text
Keywords: porphyra-334; Nrf-2; NF-κB; oxidative stress porphyra-334; Nrf-2; NF-κB; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ryu, J.; Kwon, M.-J.; Nam, T.-J. Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts. Mar. Drugs 2015, 13, 4721-4732.

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