Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
AbstractFour new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4). View Full-Text
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Won, T.H.; Kim, C.-K.; Lee, S.-H.; Rho, B.J.; Lee, S.K.; Oh, D.-C.; Oh, K.-B.; Shin, J. Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.. Mar. Drugs 2015, 13, 3836-3848.
Won TH, Kim C-K, Lee S-H, Rho BJ, Lee SK, Oh D-C, Oh K-B, Shin J. Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.. Marine Drugs. 2015; 13(6):3836-3848.Chicago/Turabian Style
Won, Tae H.; Kim, Chang-Kwon; Lee, So-Hyoung; Rho, Boon J.; Lee, Sang K.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon. 2015. "Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.." Mar. Drugs 13, no. 6: 3836-3848.