Next Article in Journal
Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry
Previous Article in Journal
Dangerous Relations in the Arctic Marine Food Web: Interactions between Toxin Producing Pseudo-nitzschia Diatoms and Calanus Copepodites
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(6), 3836-3848; doi:10.3390/md13063836

Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 21 April 2015 / Accepted: 5 June 2015 / Published: 16 June 2015
View Full-Text   |   Download PDF [349 KB, uploaded 16 June 2015]   |  

Abstract

Four new iodobenzene-containing dipeptides (14), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (15) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4). View Full-Text
Keywords: dipeptides; apliamides; Aplidium sp.; Marfey’s analysis; bioactivities dipeptides; apliamides; Aplidium sp.; Marfey’s analysis; bioactivities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Won, T.H.; Kim, C.-K.; Lee, S.-H.; Rho, B.J.; Lee, S.K.; Oh, D.-C.; Oh, K.-B.; Shin, J. Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.. Mar. Drugs 2015, 13, 3836-3848.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top