Synthesis and Bioactivity of Luffarin I
AbstractThe first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12–17 μM. View Full-Text
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Urosa, A.; Marcos, I.S.; Díez, D.; Lithgow, A.; Plata, G.B.; Padrón, J.M.; Basabe, P. Synthesis and Bioactivity of Luffarin I. Mar. Drugs 2015, 13, 2407-2423.
Urosa A, Marcos IS, Díez D, Lithgow A, Plata GB, Padrón JM, Basabe P. Synthesis and Bioactivity of Luffarin I. Marine Drugs. 2015; 13(4):2407-2423.Chicago/Turabian Style
Urosa, Aitor; Marcos, Isidro S.; Díez, David; Lithgow, Anna; Plata, Gabriela B.; Padrón, José M.; Basabe, Pilar. 2015. "Synthesis and Bioactivity of Luffarin I." Mar. Drugs 13, no. 4: 2407-2423.