Next Article in Journal
Intracellular Immunohistochemical Detection of Tetrodotoxin in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria)
Next Article in Special Issue
Seaweed Supplements Normalise Metabolic, Cardiovascular and Liver Responses in High-Carbohydrate, High-Fat Fed Rats
Previous Article in Journal
In Vivo Metabolism Study of Xiamenmycin A in Mouse Plasma by UPLC-QTOF-MS and LC-MS/MS
Previous Article in Special Issue
Impact of DHA on Metabolic Diseases from Womb to Tomb
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(2), 741-755; doi:10.3390/md13020741

The Effects of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients: A Pilot Study

Department of Internal Medicine, Dong-A University, Busan 602-715, Korea
Institute of Medical Science, Dong-A University College of Medicine, Busan 602-715, Korea
Author to whom correspondence should be addressed.
Academic Editor: Constantina Nasopoulou
Received: 25 September 2014 / Revised: 29 December 2014 / Accepted: 21 January 2015 / Published: 28 January 2015
(This article belongs to the Special Issue Marine Functional Food Products - Cardiovascular Diseases)
View Full-Text   |   Download PDF [532 KB, uploaded 24 February 2015]   |  


The high incidence of cardiovascular disease and vitamin D deficiency in chronic kidney disease patients is well known. Vitamin D activation by omega-3 fatty acid (FA) supplementation may explain the cardioprotective effects exerted by omega-3 FA. We hypothesized that omega-3 FA and 25-hydroxyvitamin D (25(OH)D) supplementation may increase 1,25-dihydroxyvitamin D (1,25(OH)2D) levels compared to 25(OH)D supplementation alone in hemodialysis (HD) patients that have insufficient or deficient 25(OH)D levels. We enrolled patients that were treated for at least six months with 25(OH)D < 30 ng/mL (NCT01596842). Patients were randomized to treatment for 12 weeks with cholecalciferol supplemented with omega-3 FA or a placebo. Levels of 25(OH)D and 1,25(OH)2D were measured after 12 weeks. The erythrocyte membrane FA contents were also measured. Levels of 25(OH)D were increased in both groups at 12 weeks compared to baseline. The 1,25(OH)2D levels at 12 weeks compared to baseline showed a tendency to increase in the omega-3 FA group. The oleic acid and monounsaturated FA content decreased, while the omega-3 index increased in the omega-3 FA group. Omega-3 FA supplementation may be partly associated with vitamin D activation, although increased 25(OH)D levels caused by short-term cholecalciferol supplementation were not associated with vitamin D activation in HD patients. View Full-Text
Keywords: omega-3 fatty acid; 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; vitamin D; hemodialysis omega-3 fatty acid; 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; vitamin D; hemodialysis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, S.M.; Son, Y.K.; Kim, S.E.; An, W.S. The Effects of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients: A Pilot Study. Mar. Drugs 2015, 13, 741-755.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top