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Mar. Drugs 2015, 13(11), 6866-6883; doi:10.3390/md13116866

Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice

1
College of Pharmacy, Mokpo National University, Muan-gun, Jeonnam 58554, Korea
2
College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon 21999, Korea
3
Korea Mouse Metabolic Phenotyping Center (KMMPC), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon 21999, Korea
4
Ocean Science & Technology School, Korea Maritime and Ocean University, Yeongdo-gu, Busan 49112, Korea
5
Gachon Medical Research Institute, Gil Hospital, Namdong-gu, Incheon 21565, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 16 September 2015 / Revised: 28 October 2015 / Accepted: 30 October 2015 / Published: 12 November 2015
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Abstract

Ecklonia cava (E. cava; CA) is an edible brown alga with beneficial effects in diabetes via regulation of various metabolic processes such as lipogenesis, lipolysis, inflammation, and the antioxidant defense system in liver and adipose tissue. We investigated the effect of the polyphenol-rich fraction of E. cava produced from Gijang (G-CA) on nonalcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-fed mice. C57BL6 mice were fed a HFD for six weeks and then the HFD group was administered 300 mg/kg of G-CA extracts by oral intubation for 10 weeks. Body weight, fat mass, and serum biochemical parameters were reduced by G-CA extract treatment. MRI/MRS analysis showed that liver fat and liver volume in HFD-induced obese mice were reduced by G-CA extract treatment. Further, we analyzed hepatic gene expression related to inflammation and lipid metabolism. The mRNA expression levels of inflammatory cytokines and hepatic lipogenesis-related genes were decreased in G-CA-treated HFD mice. The mRNA expression levels of cholesterol 7 alpha-hydroxylase 1 (CYP7A1), the key enzyme in bile acid synthesis, were dramatically increased by G-CA treatment in HFD mice. We suggest that G-CA treatment ameliorated hepatic steatosis by inhibiting inflammation and improving lipid metabolism. View Full-Text
Keywords: Ecklonia cava; hepatic steatosis; MRI; MRS; fatty liver; NAFLD Ecklonia cava; hepatic steatosis; MRI; MRS; fatty liver; NAFLD
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, E.-Y.; Choi, H.; Yoon, J.-Y.; Lee, I.-Y.; Seo, Y.; Moon, H.-S.; Hwang, J.-H.; Jun, H.-S. Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice. Mar. Drugs 2015, 13, 6866-6883.

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