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Mar. Drugs 2015, 13(11), 6884-6909; doi:10.3390/md13116884

Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

1
Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt
2
Institut National de la Santé et de la Recherche Médicale, UMR866, Dijon F-21079, France
3
Unité de Formation et de Recherche, Science de Santé, Dijon F-21079, France
*
Author to whom correspondence should be addressed.
Academic Editor: Keith Glaser
Received: 21 September 2015 / Revised: 2 November 2015 / Accepted: 9 November 2015 / Published: 13 November 2015
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Abstract

Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells. View Full-Text
Keywords: TNF; TRAIL; Apoptosis; resistance; cancer; marine drugs; alkaloids; carotenoids; sesquiterpenes; macrolactones TNF; TRAIL; Apoptosis; resistance; cancer; marine drugs; alkaloids; carotenoids; sesquiterpenes; macrolactones
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Elmallah, M.I.Y.; Micheau, O. Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Mar. Drugs 2015, 13, 6884-6909.

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