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Mar. Drugs 2015, 13(1), 444-459; doi:10.3390/md13010444

Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea

1
The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
2
Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Alejandro M. Mayer
Received: 3 December 2014 / Accepted: 4 January 2015 / Published: 16 January 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
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Abstract

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism. View Full-Text
Keywords: Smenospongia aurea; marine natural products; thiazole; structure elucidation; anti-tumor lead molecules; smenamides; solid tumor cell lines; apoptosis; MTT assays Smenospongia aurea; marine natural products; thiazole; structure elucidation; anti-tumor lead molecules; smenamides; solid tumor cell lines; apoptosis; MTT assays
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Esposito, G.; Teta, R.; Miceli, R.; Ceccarelli, L.S.; Della Sala, G.; Camerlingo, R.; Irollo, E.; Mangoni, A.; Pirozzi, G.; Costantino, V. Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea. Mar. Drugs 2015, 13, 444-459.

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