Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury
AbstractNeonatal hypoxic-ischemic encephalopathy causes neurodegeneration and brain injury, leading to sensorimotor dysfunction. Xyloketal B is a novel marine compound isolated from a mangrove fungus Xylaria species (no. 2508) with unique antioxidant effects. In this study, we investigated the effects and mechanism of xyloketal B on oxygen-glucose deprivation-induced neuronal cell death in mouse primary cortical culture and on hypoxic-ischemic brain injury in neonatal mice in vivo. We found that xyloketal B reduced anoxia-induced neuronal cell death in vitro, as well as infarct volume in neonatal hypoxic-ischemic brain injury model in vivo. Furthermore, xyloketal B improved functional behavioral recovery of the animals following hypoxic-ischemic insult. In addition, xyloketal B significantly decreased calcium entry, reduced the number of TUNEL-positive cells, reduced the levels of cleaved caspase-3 and Bax proteins, and increased the level of Bcl-2 protein after the hypoxic-ischemic injury. Our findings indicate that xyloketal B is effective in models of hypoxia-ischemia and thus has potential as a treatment for hypoxic-ischemic brain injury. View Full-Text
Share & Cite This Article
Xiao, A.-J.; Chen, W.; Xu, B.; Liu, R.; Turlova, E.; Barszczyk, A.; Sun, C.L.; Liu, L.; Deurloo, M.; Wang, G.-L.; Feng, Z.-P.; Sun, H.-S. Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury. Mar. Drugs 2015, 13, 29-47.
Xiao A-J, Chen W, Xu B, Liu R, Turlova E, Barszczyk A, Sun CL, Liu L, Deurloo M, Wang G-L, Feng Z-P, Sun H-S. Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury. Marine Drugs. 2015; 13(1):29-47.Chicago/Turabian Style
Xiao, Ai-Jiao; Chen, Wenliang; Xu, Baofeng; Liu, Rui; Turlova, Ekaterina; Barszczyk, Andrew; Sun, Christopher L.; Liu, Ling; Deurloo, Marielle; Wang, Guan-Lei; Feng, Zhong-Ping; Sun, Hong-Shuo. 2015. "Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury." Mar. Drugs 13, no. 1: 29-47.