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Mar. Drugs 2015, 13(1), 276-287; doi:10.3390/md13010276

Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae

1,2,†
,
1,2,†
,
1
and
1,*
1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Khalid A. El Sayed
Received: 6 December 2014 / Accepted: 25 December 2014 / Published: 7 January 2015
View Full-Text   |   Download PDF [771 KB, uploaded 24 February 2015]   |  

Abstract

Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (15), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 26 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL. View Full-Text
Keywords: mangrove plant; endophytic fungus; Pencillium brocae; secondary metabolites; antimicrobial activity mangrove plant; endophytic fungus; Pencillium brocae; secondary metabolites; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Meng, L.-H.; Zhang, P.; Li, X.-M.; Wang, B.-G. Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae. Mar. Drugs 2015, 13, 276-287.

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