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Mar. Drugs 2014, 12(9), 4934-4972; doi:10.3390/md12094934

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
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Received: 18 June 2014 / Revised: 5 September 2014 / Accepted: 15 September 2014 / Published: 25 September 2014
(This article belongs to the Special Issue Marine Secondary Metabolites)

Abstract

Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases. View Full-Text
Keywords: macroalgae; neuroprotection; neurodegeneration; neuroinflammation; oxidative/nitrosative damage; cholinesterase; Alzheimer’s; Parkinson’s macroalgae; neuroprotection; neurodegeneration; neuroinflammation; oxidative/nitrosative damage; cholinesterase; Alzheimer’s; Parkinson’s
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Barbosa, M.; Valentão, P.; Andrade, P.B. Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases. Mar. Drugs 2014, 12, 4934-4972.

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