Next Article in Journal
Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
Previous Article in Journal
Inactivation of Heparin by Cationically Modified Chitosan
Article Menu

Export Article

Open AccessCommunication
Mar. Drugs 2014, 12(7), 3970-3981; doi:10.3390/md12073970

Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei

1,†
,
1,†
,
2
,
1
,
1
and
1,*
1
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Key Lab of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 April 2014 / Revised: 3 June 2014 / Accepted: 13 June 2014 / Published: 30 June 2014
View Full-Text   |   Download PDF [473 KB, uploaded 24 February 2015]   |  

Abstract

Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation broth of the marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures of Compounds 112 were elucidated by spectroscopic analyses, quantum ECD calculations and the chemical method. New Compound 1 exhibited antibacterial activity against Staphylococcus aureus with a MIC value of 20.5 μM. Both new Compounds 1 and 2 could arrest the A549 cell cycle in the S phase at a concentration of 10 μM. Compound 1 showed PKC-beta inhibition with an IC50 value of 15.6 μM. In addition, the absolute configurations of the known compounds, 46 and leporin A (6a), were also determined for the first time. View Full-Text
Keywords: Penaeus vannamei; endophytic fungus Aspergillus flavus; indole-diterpenoids; bioactivity Penaeus vannamei; endophytic fungus Aspergillus flavus; indole-diterpenoids; bioactivity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sun, K.; Li, Y.; Guo, L.; Wang, Y.; Liu, P.; Zhu, W. Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei. Mar. Drugs 2014, 12, 3970-3981.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top