Mar. Drugs 2014, 12(6), 3516-3559; doi:10.3390/md12063516
Review

Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds

1email, 1email, 2,3email and 1,2,3,4,* email
Received: 8 April 2014; in revised form: 21 May 2014 / Accepted: 22 May 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract: Marine microorganisms continue to be a source of structurally and biologically novel compounds with potential use in the biotechnology industry. The unique physiochemical properties of the marine environment (such as pH, pressure, temperature, osmolarity) and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are frequently found in marine metabolites. These facts have resulted in the production of bioactive substances with different properties than those found in terrestrial habitats. In fact, the marine environment contains a relatively untapped reservoir of bioactivity. Recent advances in genomics, metagenomics, proteomics, combinatorial biosynthesis, synthetic biology, screening methods, expression systems, bioinformatics, and the ever increasing availability of sequenced genomes provides us with more opportunities than ever in the discovery of novel bioactive compounds and biocatalysts. The combination of these advanced techniques with traditional techniques, together with the use of dereplication strategies to eliminate known compounds, provides a powerful tool in the discovery of novel marine bioactive compounds. This review outlines and discusses the emerging strategies for the biodiscovery of these bioactive compounds.
Keywords: marine bioactive compounds; metagenomics; synthetic biology; biocatalyst discovery; metaproteomic; dereplication; omic approaches
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rocha-Martin, J.; Harrington, C.; Dobson, A.D.; O'Gara, F. Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds. Mar. Drugs 2014, 12, 3516-3559.

AMA Style

Rocha-Martin J, Harrington C, Dobson AD, O'Gara F. Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds. Marine Drugs. 2014; 12(6):3516-3559.

Chicago/Turabian Style

Rocha-Martin, Javier; Harrington, Catriona; Dobson, Alan D.; O'Gara, Fergal. 2014. "Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds." Mar. Drugs 12, no. 6: 3516-3559.


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