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Mar. Drugs 2014, 12(6), 3283-3291; doi:10.3390/md12063283
Article

Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci

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Received: 18 March 2014 / Revised: 8 May 2014 / Accepted: 16 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract

Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (14) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
Keywords: Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shin, H.J.; Lee, H.-S.; Lee, J.S.; Shin, J.; Lee, M.A.; Lee, H.-S.; Lee, Y.-J.; Yun, J.; Kang, J.S. Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci. Mar. Drugs 2014, 12, 3283-3291.

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