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Mar. Drugs 2014, 12(6), 3283-3291; doi:10.3390/md12063283

Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci

Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea
Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Daejeon 305-350, Korea
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, Korea
Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 8 May 2014 / Accepted: 16 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (14) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C. View Full-Text
Keywords: Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shin, H.J.; Lee, H.-S.; Lee, J.S.; Shin, J.; Lee, M.A.; Lee, H.-S.; Lee, Y.-J.; Yun, J.; Kang, J.S. Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci. Mar. Drugs 2014, 12, 3283-3291.

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