Next Article in Journal
The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy
Next Article in Special Issue
Eurothiocin A and B, Sulfur-Containing Benzofurans from a Soft Coral-Derived Fungus Eurotium rubrum SH-823
Previous Article in Journal
Quorum Quenching Agents: Resources for Antivirulence Therapy
Previous Article in Special Issue
Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions
Mar. Drugs 2014, 12(6), 3283-3291; doi:10.3390/md12063283
Article

Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci

1,2,* , 1
, 1
, 1
, 1
, 1
, 1
, 3
 and 3
1 Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea 2 Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Daejeon 305-350, Korea 3 Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, Korea
* Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 8 May 2014 / Accepted: 16 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
View Full-Text   |   Download PDF [614 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (14) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
Keywords: Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Shin, H.J.; Lee, H.-S.; Lee, J.S.; Shin, J.; Lee, M.A.; Lee, H.-S.; Lee, Y.-J.; Yun, J.; Kang, J.S. Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci. Mar. Drugs 2014, 12, 3283-3291.

View more citation formats

Supplement

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert