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Mar. Drugs 2014, 12(6), 3283-3291; doi:10.3390/md12063283
Article

Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci

1,2,* , 1
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,
1
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1 Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea 2 Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Daejeon 305-350, Korea 3 Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, Korea
* Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 8 May 2014 / Accepted: 16 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract

Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (14) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
Keywords: Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish Streptomyces sp.; violapyrones; anti-cancer activity; α-pyrones; starfish
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shin, H.J.; Lee, H.-S.; Lee, J.S.; Shin, J.; Lee, M.A.; Lee, H.-S.; Lee, Y.-J.; Yun, J.; Kang, J.S. Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci. Mar. Drugs 2014, 12, 3283-3291.

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