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Mar. Drugs 2014, 12(6), 3669-3680; https://doi.org/10.3390/md12063669

Eurothiocin A and B, Sulfur-Containing Benzofurans from a Soft Coral-Derived Fungus Eurotium rubrum SH-823

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
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Received: 30 April 2014 / Revised: 3 June 2014 / Accepted: 13 June 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract

Two new sulfur-containing benzofuran derivatives, eurothiocin A and B (1 and 2), along with five known compounds, zinniol (3), butyrolactone I (4), aspernolide D (5), vermistatin (6), and methoxyvermistatin (7), were isolated from the cultures of Eurotium rubrum SH-823, a fungus obtained from a Sarcophyton sp. soft coral collected from the South China Sea. The new compounds (1 and 2) share a methyl thiolester moiety, which is quite rare among natural secondary metabolites. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute configurations of 1 and 2 were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) data. Compounds 1 and 2 exhibited more potent inhibitory effects against α-glucosidase activity than the clinical α-glucosidase inhibitor acarbose. Further mechanistic analysis showed that both of them exhibited competitive inhibition characteristics. View Full-Text
Keywords: marine fungi; secondary metabolites; α-glucosidase inhibitor; theoretical calculations; ECD; TDDFT marine fungi; secondary metabolites; α-glucosidase inhibitor; theoretical calculations; ECD; TDDFT
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Liu, Z.; Xia, G.; Chen, S.; Liu, Y.; Li, H.; She, Z. Eurothiocin A and B, Sulfur-Containing Benzofurans from a Soft Coral-Derived Fungus Eurotium rubrum SH-823. Mar. Drugs 2014, 12, 3669-3680.

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