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Mar. Drugs 2014, 12(5), 2816-2826; doi:10.3390/md12052816
Article

Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus

1,2
,
2
,
2
,
2
 and
2,*
1 College of Chemistry & Pharmacy, Qingdao Agricultural University, Qingdao 266109, China 2 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 2 February 2014 / Revised: 25 March 2014 / Accepted: 28 April 2014 / Published: 13 May 2014
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Abstract

Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (47). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
Keywords: marine fungus; bryozoan; Beauveria felina; secondary metabolites; bioactivity marine fungus; bryozoan; Beauveria felina; secondary metabolites; bioactivity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Du, F.-Y.; Li, X.-M.; Zhang, P.; Li, C.-S.; Wang, B.-G. Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus. Mar. Drugs 2014, 12, 2816-2826.

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