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Mar. Drugs 2014, 12(5), 2802-2815; doi:10.3390/md12052802
Article

A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole

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Received: 7 February 2014; in revised form: 23 April 2014 / Accepted: 24 April 2014 / Published: 13 May 2014
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Abstract: The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4′-((3,4,5-tribromo-1H-pyrrol-2-yl) methyl)phenol (1) and five new korormicins G–K (26). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A–E, previously named 1, 1a–c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 16, TBP and BAC-A was assessed. Compounds 16 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.
Keywords: Pseudoalteromonas; korormicin; bromopyrrole; bromoalterochromide; antibacterial; antifungal; antiprotozoal Pseudoalteromonas; korormicin; bromopyrrole; bromoalterochromide; antibacterial; antifungal; antiprotozoal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tebben, J.; Motti, C.; Tapiolas, D.; Thomas-Hall, P.; Harder, T. A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole. Mar. Drugs 2014, 12, 2802-2815.

AMA Style

Tebben J, Motti C, Tapiolas D, Thomas-Hall P, Harder T. A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole. Marine Drugs. 2014; 12(5):2802-2815.

Chicago/Turabian Style

Tebben, Jan; Motti, Cherie; Tapiolas, Dianne; Thomas-Hall, Peter; Harder, Tilmann. 2014. "A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole." Mar. Drugs 12, no. 5: 2802-2815.



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