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Mar. Drugs 2014, 12(5), 2802-2815; doi:10.3390/md12052802

A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole

1
School of Biological, Earth and Environmental Sciences and Centre for Marine Bio-Innovation, The University of New South Wales, Sydney, NSW 2052, Australia
2
Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia
*
Author to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 23 April 2014 / Accepted: 24 April 2014 / Published: 13 May 2014
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Abstract

The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4′-((3,4,5-tribromo-1H-pyrrol-2-yl) methyl)phenol (1) and five new korormicins G–K (26). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A–E, previously named 1, 1a–c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 16, TBP and BAC-A was assessed. Compounds 16 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.
Keywords: Pseudoalteromonas; korormicin; bromopyrrole; bromoalterochromide; antibacterial; antifungal; antiprotozoal Pseudoalteromonas; korormicin; bromopyrrole; bromoalterochromide; antibacterial; antifungal; antiprotozoal
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MDPI and ACS Style

Tebben, J.; Motti, C.; Tapiolas, D.; Thomas-Hall, P.; Harder, T. A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole. Mar. Drugs 2014, 12, 2802-2815.

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