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Mar. Drugs 2014, 12(5), 2760-2770; doi:10.3390/md12052760
Article

New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis

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Received: 11 February 2014; in revised form: 26 March 2014 / Accepted: 21 April 2014 / Published: 12 May 2014
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Abstract: Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca- and undecapeptides. The absolute configurations of all amino acid residues were determined to be l by advanced Marfey’s analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na+/K+-ATPase.
Keywords: Suberites waedoensis; cyclic cystine bridged peptides; chujamides; cytotoxicity; Na+/K+-ATPase Suberites waedoensis; cyclic cystine bridged peptides; chujamides; cytotoxicity; Na+/K+-ATPase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Song, J.; Jeon, J.-E.; Won, T.H.; Sim, C.J.; Oh, D.-C.; Oh, K.-B.; Shin, J. New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis. Mar. Drugs 2014, 12, 2760-2770.

AMA Style

Song J, Jeon J-E, Won TH, Sim CJ, Oh D-C, Oh K-B, Shin J. New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis. Marine Drugs. 2014; 12(5):2760-2770.

Chicago/Turabian Style

Song, Jinhaeng; Jeon, Ju-eun; Won, Tae H.; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon. 2014. "New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis." Mar. Drugs 12, no. 5: 2760-2770.



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