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Mar. Drugs 2014, 12(5), 2760-2770; doi:10.3390/md12052760

New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
3
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
*
Authors to whom correspondence should be addressed.
Received: 11 February 2014 / Revised: 26 March 2014 / Accepted: 21 April 2014 / Published: 12 May 2014
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Abstract

Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca- and undecapeptides. The absolute configurations of all amino acid residues were determined to be l by advanced Marfey’s analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na+/K+-ATPase.
Keywords: Suberites waedoensis; cyclic cystine bridged peptides; chujamides; cytotoxicity; Na+/K+-ATPase Suberites waedoensis; cyclic cystine bridged peptides; chujamides; cytotoxicity; Na+/K+-ATPase
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MDPI and ACS Style

Song, J.; Jeon, J.-E.; Won, T.H.; Sim, C.J.; Oh, D.-C.; Oh, K.-B.; Shin, J. New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis. Mar. Drugs 2014, 12, 2760-2770.

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