Mar. Drugs 2014, 12(5), 2748-2759; doi:10.3390/md12052748

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens

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Received: 17 February 2014; in revised form: 6 April 2014 / Accepted: 8 April 2014 / Published: 12 May 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Lyngbyatoxin A from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) is known as the causative agent of “swimmer’s itch” with its highly inflammatory effect. A new toxic compound was isolated along with lyngbyatoxin A from an ethyl acetate extract of M. producens collected from Hawaii. Analyses of HR-ESI-MS and NMR spectroscopies revealed the isolated compound had the same planar structure with that of lyngbyatoxin A. The results of optical rotation and CD spectra indicated that the compound was a new lyngbyatoxin A derivative, 12-epi-lyngbyatoxin A (1). While 12-epi-lyngbyatoxin A showed comparable toxicities with lyngbyatoxin A in cytotoxicity and crustacean lethality tests, it showed more than 100 times lower affinity for protein kinase Cδ (PKCδ) using the PKCδ-C1B peptide when compared to lyngbyatoxin A.
Keywords: lyngbyatoxin A; cyanobacteria; Moorea producens; toxicity; protein kinase C
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MDPI and ACS Style

Jiang, W.; Zhou, W.; Uchida, H.; Kikumori, M.; Irie, K.; Watanabe, R.; Suzuki, T.; Sakamoto, B.; Kamio, M.; Nagai, H. A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens. Mar. Drugs 2014, 12, 2748-2759.

AMA Style

Jiang W, Zhou W, Uchida H, Kikumori M, Irie K, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H. A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens. Marine Drugs. 2014; 12(5):2748-2759.

Chicago/Turabian Style

Jiang, Weina; Zhou, Wei; Uchida, Hajime; Kikumori, Masayuki; Irie, Kazuhiro; Watanabe, Ryuichi; Suzuki, Toshiyuki; Sakamoto, Bryan; Kamio, Michiya; Nagai, Hiroshi. 2014. "A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens." Mar. Drugs 12, no. 5: 2748-2759.

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