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Mar. Drugs 2014, 12(5), 2748-2759; doi:10.3390/md12052748
Communication

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens

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Received: 17 February 2014; in revised form: 6 April 2014 / Accepted: 8 April 2014 / Published: 12 May 2014
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Abstract: Lyngbyatoxin A from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) is known as the causative agent of “swimmer’s itch” with its highly inflammatory effect. A new toxic compound was isolated along with lyngbyatoxin A from an ethyl acetate extract of M. producens collected from Hawaii. Analyses of HR-ESI-MS and NMR spectroscopies revealed the isolated compound had the same planar structure with that of lyngbyatoxin A. The results of optical rotation and CD spectra indicated that the compound was a new lyngbyatoxin A derivative, 12-epi-lyngbyatoxin A (1). While 12-epi-lyngbyatoxin A showed comparable toxicities with lyngbyatoxin A in cytotoxicity and crustacean lethality tests, it showed more than 100 times lower affinity for protein kinase Cδ (PKCδ) using the PKCδ-C1B peptide when compared to lyngbyatoxin A.
Keywords: lyngbyatoxin A; cyanobacteria; Moorea producens; toxicity; protein kinase C lyngbyatoxin A; cyanobacteria; Moorea producens; toxicity; protein kinase C
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jiang, W.; Zhou, W.; Uchida, H.; Kikumori, M.; Irie, K.; Watanabe, R.; Suzuki, T.; Sakamoto, B.; Kamio, M.; Nagai, H. A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens. Mar. Drugs 2014, 12, 2748-2759.

AMA Style

Jiang W, Zhou W, Uchida H, Kikumori M, Irie K, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H. A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens. Marine Drugs. 2014; 12(5):2748-2759.

Chicago/Turabian Style

Jiang, Weina; Zhou, Wei; Uchida, Hajime; Kikumori, Masayuki; Irie, Kazuhiro; Watanabe, Ryuichi; Suzuki, Toshiyuki; Sakamoto, Bryan; Kamio, Michiya; Nagai, Hiroshi. 2014. "A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens." Mar. Drugs 12, no. 5: 2748-2759.


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