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Mar. Drugs 2014, 12(5), 2515-2525; doi:10.3390/md12052515
Article

Four New Jacaranone Analogs from the Fruits of a Beibu Gulf Mangrove Avicennia marina

1
,
1
,
1,2
,
2
,
3
,
2
 and
3,4,*
1 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530007, China 2 Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China 3 Key Laboratory of Plant Resource Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China 4 Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
* Author to whom correspondence should be addressed.
Received: 31 December 2013 / Revised: 10 April 2014 / Accepted: 16 April 2014 / Published: 30 April 2014
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Abstract

Four new jacaranone analogs, marinoids F–I (14), were isolated from the fruits of a Beibu Gulf mangrove Avicennia marina. The structures were elucidated based on analysis of spectroscopic data. Marinoids F and G are shown to be diastereoisomers of chlorocornoside, a new halogen containing marine secondary metabolite. The antioxidant activity of the isolates was evaluated using a cellular antioxidant assay, and 4 showed good antioxidant activity (EC50 = 26 μM).
Keywords: antioxidant; Avicennia marina; chlorocornoside; cornoside; jacaranone analogs; marinoid antioxidant; Avicennia marina; chlorocornoside; cornoside; jacaranone analogs; marinoid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yi, X.-X.; Chen, Y.; Xie, W.-P.; Xu, M.-B.; Chen, Y.-N.; Gao, C.-H.; Huang, R.-M. Four New Jacaranone Analogs from the Fruits of a Beibu Gulf Mangrove Avicennia marina. Mar. Drugs 2014, 12, 2515-2525.

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