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Mar. Drugs 2014, 12(5), 2446-2457; doi:10.3390/md12052446
Article

Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta

1,†
,
1,†
,
1
,
2
,
3
 and
1,4,5,6,7,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 3 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 4 Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan 7 Asia Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 February 2014 / Revised: 24 March 2014 / Accepted: 31 March 2014 / Published: 30 April 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract

New eunicellin-type hirsutalins N–R (15), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 17 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 17 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
Keywords: soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, T.-Z.; Chen, B.-W.; Huang, C.-Y.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta. Mar. Drugs 2014, 12, 2446-2457.

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