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Mar. Drugs 2014, 12(5), 2446-2457; doi:10.3390/md12052446
Article

Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta

1,†
, 1,†
, 1
, 2
, 3
 and 1,4,5,6,7,*
Received: 13 February 2014; in revised form: 24 March 2014 / Accepted: 31 March 2014 / Published: 30 April 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract: New eunicellin-type hirsutalins N–R (15), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 17 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 17 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
Keywords: soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, T.-Z.; Chen, B.-W.; Huang, C.-Y.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta. Mar. Drugs 2014, 12, 2446-2457.

AMA Style

Huang T-Z, Chen B-W, Huang C-Y, Hwang T-L, Dai C-F, Sheu J-H. Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta. Marine Drugs. 2014; 12(5):2446-2457.

Chicago/Turabian Style

Huang, Tzu-Zin; Chen, Bo-Wei; Huang, Chiung-Yao; Hwang, Tsong-Long; Dai, Chang-Feng; Sheu, Jyh-Horng. 2014. "Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta." Mar. Drugs 12, no. 5: 2446-2457.



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