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Mar. Drugs 2014, 12(3), 1208-1219; doi:10.3390/md12031208

Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

1 Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany 2 Ocean College, Zhejiang University, Hangzhou 310058, China
* Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 22 January 2014 / Accepted: 11 February 2014 / Published: 6 March 2014
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Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.
Keywords: pyridones; antibiotic; Trichoderma; marine fungus pyridones; antibiotic; Trichoderma; marine fungus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wu, B.; Oesker, V.; Wiese, J.; Schmaljohann, R.; Imhoff, J.F. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Mar. Drugs 2014, 12, 1208-1219.

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