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Mar. Drugs 2014, 12(3), 1208-1219; doi:10.3390/md12031208
Article

Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

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Received: 19 December 2013; in revised form: 22 January 2014 / Accepted: 11 February 2014 / Published: 6 March 2014
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Abstract: Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.
Keywords: pyridones; antibiotic; Trichoderma; marine fungus pyridones; antibiotic; Trichoderma; marine fungus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, B.; Oesker, V.; Wiese, J.; Schmaljohann, R.; Imhoff, J.F. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Mar. Drugs 2014, 12, 1208-1219.

AMA Style

Wu B, Oesker V, Wiese J, Schmaljohann R, Imhoff JF. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Marine Drugs. 2014; 12(3):1208-1219.

Chicago/Turabian Style

Wu, Bin; Oesker, Vanessa; Wiese, Jutta; Schmaljohann, Rolf; Imhoff, Johannes F. 2014. "Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106." Mar. Drugs 12, no. 3: 1208-1219.


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