Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
AbstractTwo unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.
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Wu, B.; Oesker, V.; Wiese, J.; Schmaljohann, R.; Imhoff, J.F. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Mar. Drugs 2014, 12, 1208-1219.
Wu B, Oesker V, Wiese J, Schmaljohann R, Imhoff JF. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Marine Drugs. 2014; 12(3):1208-1219.Chicago/Turabian Style
Wu, Bin; Oesker, Vanessa; Wiese, Jutta; Schmaljohann, Rolf; Imhoff, Johannes F. 2014. "Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106." Mar. Drugs 12, no. 3: 1208-1219.