Mar. Drugs 2014, 12(2), 1013-1022; doi:10.3390/md12021013
Article

Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

1,†email, 1,†email, 2email, 1email and 1,* email
Received: 19 December 2013; in revised form: 24 January 2014 / Accepted: 24 January 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-13C glucose, and analysis of a 13C–13C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
Keywords: Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus
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MDPI and ACS Style

Ellis, G.A.; Wyche, T.P.; Fry, C.G.; Braun, D.R.; Bugni, T.S. Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.. Mar. Drugs 2014, 12, 1013-1022.

AMA Style

Ellis GA, Wyche TP, Fry CG, Braun DR, Bugni TS. Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.. Marine Drugs. 2014; 12(2):1013-1022.

Chicago/Turabian Style

Ellis, Gregory A.; Wyche, Thomas P.; Fry, Charles G.; Braun, Doug R.; Bugni, Tim S. 2014. "Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.." Mar. Drugs 12, no. 2: 1013-1022.


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