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Mar. Drugs 2014, 12(2), 1013-1022; doi:10.3390/md12021013
Article

Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

1,†
, 1,†
, 2
, 1
 and 1,*
1 Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA 2 Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 24 January 2014 / Accepted: 24 January 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-13C glucose, and analysis of a 13C–13C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
Keywords: Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ellis, G.A.; Wyche, T.P.; Fry, C.G.; Braun, D.R.; Bugni, T.S. Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.. Mar. Drugs 2014, 12, 1013-1022.

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