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Mar. Drugs 2014, 12(2), 999-1012; doi:10.3390/md12020999
Article

Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

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Received: 22 November 2013; in revised form: 24 December 2013 / Accepted: 21 January 2014 / Published: 14 February 2014
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Abstract: A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
Keywords: Micromonospora; macrolactam; tautomer; tetramic acid; mangroves Micromonospora; macrolactam; tautomer; tetramic acid; mangroves
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kyeremeh, K.; Acquah, K.S.; Sazak, A.; Houssen, W.; Tabudravu, J.; Deng, H.; Jaspars, M. Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310. Mar. Drugs 2014, 12, 999-1012.

AMA Style

Kyeremeh K, Acquah KS, Sazak A, Houssen W, Tabudravu J, Deng H, Jaspars M. Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310. Marine Drugs. 2014; 12(2):999-1012.

Chicago/Turabian Style

Kyeremeh, Kwaku; Acquah, Kojo S.; Sazak, Anil; Houssen, Wael; Tabudravu, Jioji; Deng, Hai; Jaspars, Marcel. 2014. "Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310." Mar. Drugs 12, no. 2: 999-1012.


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