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Mar. Drugs 2014, 12(12), 6102-6112; doi:10.3390/md12126102

Anti-Mycobacterial Nucleoside Antibiotics from a Marine-Derived Streptomyces sp. TPU1236A

Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan
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Received: 30 October 2014 / Revised: 9 December 2014 / Accepted: 10 December 2014 / Published: 17 December 2014
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Abstract

Five new nucleoside antibiotics, named streptcytosines A–E (15), and six known compounds, de-amosaminyl-cytosamine (6), plicacetin (7), bamicetin (8), amicetin (9), collismycin B (10), and SF2738 C (11), were isolated from a culture broth of Streptomyces sp. TPU1236A collected in Okinawa, Japan. The structures of new compounds were elucidated on the basis of their spectroscopic data (HRFABMS, IR, UV, and 2D NMR experiments including 1H-1H COSY, HMQC, HMBC, and NOESY spectra). Streptcytosine A (1) belonged to the amicetin group antibiotics, and streptcytosines B–E (25) were derivatives of de-amosaminyl-cytosamine (6), 2,3,6-trideoxyglucopyranosyl cytosine. Compound 1 inhibited the growth of Mycobacterium smegmatis (MIC = 32 µg/mL), while compounds 25 were not active at 50 µg/disc. Bamicetin (8) and amicetin (9) showed the MICs of 16 and 8 µg/mL, respectively. View Full-Text
Keywords: marine-derived actinomycete; Streptomyces sp.; streptcytosines A–E; anti-mycobacterium activity; amicetin marine-derived actinomycete; Streptomyces sp.; streptcytosines A–E; anti-mycobacterium activity; amicetin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bu, Y.-Y.; Yamazaki, H.; Ukai, K.; Namikoshi, M. Anti-Mycobacterial Nucleoside Antibiotics from a Marine-Derived Streptomyces sp. TPU1236A. Mar. Drugs 2014, 12, 6102-6112.

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