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Mar. Drugs 2014, 12(12), 6113-6124; doi:10.3390/md12126113

Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus

1
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China
2
Jinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, China
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Revised: 24 November 2014 / Accepted: 8 December 2014 / Published: 17 December 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract

Seventeen lactones including eight territrem derivatives (18) and nine butyrolactone derivatives (917) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 13 and 910 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 117 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL−1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL−1 toward barnacle Balanus amphitrite larvae, respectively. View Full-Text
Keywords: Aspergillus terreus; anti-acetylcholinesterase; anti-HSV-1; antifouling; butyrolactone derivative; territrem derivative Aspergillus terreus; anti-acetylcholinesterase; anti-HSV-1; antifouling; butyrolactone derivative; territrem derivative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nong, X.-H.; Wang, Y.-F.; Zhang, X.-Y.; Zhou, M.-P.; Xu, X.-Y.; Qi, S.-H. Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus. Mar. Drugs 2014, 12, 6113-6124.

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