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Mar. Drugs 2014, 12(12), 5930-5943; doi:10.3390/md12125930

Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum

1
Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia
2
Far Eastern Federal University, Suhanova 8, Vladivostok 690950, Russia
*
Author to whom correspondence should be addressed.
Received: 24 September 2014 / Revised: 21 November 2014 / Accepted: 2 December 2014 / Published: 9 December 2014
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Abstract

Seven new 6,6-spiroketals, sargassopenillines A–G (17) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM. View Full-Text
Keywords: marine fungi; Penicillium thomii; Penicillium lividum; 6,6-spiroketals marine fungi; Penicillium thomii; Penicillium lividum; 6,6-spiroketals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhuravleva, O.I.; Sobolevskaya, M.P.; Afiyatullov, S.S.; Kirichuk, N.N.; Denisenko, V.A.; Dmitrenok, P.S.; Yurchenko, E.A.; Dyshlovoy, S.A. Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum. Mar. Drugs 2014, 12, 5930-5943.

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