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Mar. Drugs 2014, 12(12), 5864-5880; doi:10.3390/md12125864

Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity

1
Post-Graduation Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil
2
Invertebrates Department, National Museum, Federal University of Rio de Janeiro, Rio de Janeiro 20940-040, RJ, Brazil
3
UMYMFOR—Department of Organic Chemistry, FCEN, University of Buenos Aires, Buenos Aires C1428EGA, Argentina
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 August 2014 / Revised: 19 November 2014 / Accepted: 20 November 2014 / Published: 4 December 2014
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Abstract

Five new polyoxygenated marine steroids—punicinols A–E (15)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. View Full-Text
Keywords: Leptogorgia punicea; octocoral; polyoxygenated steroids; cytotoxic effects; A549 cells; lung cancer cells Leptogorgia punicea; octocoral; polyoxygenated steroids; cytotoxic effects; A549 cells; lung cancer cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Moritz, M.I.G.; Marostica, L.L.; Bianco, É.M.; Almeida, M.T.R.; Carraro, J.L.; Cabrera, G.M.; Palermo, J.A.; Simões, C.M.O.; Schenkel, E.P. Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity. Mar. Drugs 2014, 12, 5864-5880.

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