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Mar. Drugs 2014, 12(1), 385-393; doi:10.3390/md12010385

Discovery of Novel Diterpenoids from Sinularia arborea

1
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
4
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
5
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
6
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan
7
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
9
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
10
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
11
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
12
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
13
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Received: 5 November 2013 / Revised: 23 November 2013 / Accepted: 3 January 2014 / Published: 17 January 2014
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Abstract

Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils. View Full-Text
Keywords: sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, K.-H.; Dai, C.-F.; Hwang, T.-L.; Chen, C.-Y.; Li, J.-J.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.; Wang, W.-H.; Sung, P.-J. Discovery of Novel Diterpenoids from Sinularia arborea. Mar. Drugs 2014, 12, 385-393.

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