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Discovery of Novel Diterpenoids from Sinularia arborea
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Author to whom correspondence should be addressed.
Received: 5 November 2013; in revised form: 23 November 2013 / Accepted: 3 January 2014 / Published: 17 January 2014
Abstract: Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils.
Keywords: sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion
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Chen, K.-H.; Dai, C.-F.; Hwang, T.-L.; Chen, C.-Y.; Li, J.-J.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.; Wang, W.-H.; Sung, P.-J. Discovery of Novel Diterpenoids from Sinularia arborea. Mar. Drugs 2014, 12, 385-393.
Chen K-H, Dai C-F, Hwang T-L, Chen C-Y, Li J-J, Chen J-J, Wu Y-C, Sheu J-H, Wang W-H, Sung P-J. Discovery of Novel Diterpenoids from Sinularia arborea. Marine Drugs. 2014; 12(1):385-393.
Chen, Kuan-Hua; Dai, Chang-Feng; Hwang, Tsong-Long; Chen, Chun-Yu; Li, Jan-Jung; Chen, Jih-Jung; Wu, Yang-Chang; Sheu, Jyh-Horng; Wang, Wei-Hsien; Sung, Ping-Jyun. 2014. "Discovery of Novel Diterpenoids from Sinularia arborea." Mar. Drugs 12, no. 1: 385-393.