Mar. Drugs 2014, 12(1), 232-254; doi:10.3390/md12010232

Holothurian Fucosylated Chondroitin Sulfate

Received: 5 November 2013; in revised form: 23 December 2013 / Accepted: 30 December 2013 / Published: 9 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates. However, FucCS has also sulfated fucosyl branching units 3-O-linked to the acid residues. The sulfation patterns of these branches vary accordingly with holothurian species and account for different biological actions and responses. FucCSs may exhibit anticoagulant, antithrombotic, anti-inflammatory, anticancer, antiviral, and pro-angiogenic activities, besides its beneficial effects in hemodialysis, cellular growth modulation, fibrosis and hyperglycemia. Through an historical overview, this document covers most of the science regarding the holothurian FucCS. Both structural and medical properties of this unique GAG, investigated during the last 25 years, are systematically discussed herein.
Keywords: carbohydrate-based drug development; chondroitin sulfate; fucose; sulfated glycosaminoglycan; echinoderm; therapeutic actions
PDF Full-text Download PDF Full-Text [668 KB, uploaded 9 January 2014 14:55 CET]

Export to BibTeX |

MDPI and ACS Style

Pomin, V.H. Holothurian Fucosylated Chondroitin Sulfate. Mar. Drugs 2014, 12, 232-254.

AMA Style

Pomin VH. Holothurian Fucosylated Chondroitin Sulfate. Marine Drugs. 2014; 12(1):232-254.

Chicago/Turabian Style

Pomin, Vitor H. 2014. "Holothurian Fucosylated Chondroitin Sulfate." Mar. Drugs 12, no. 1: 232-254.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert