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Mar. Drugs 2014, 12(2), 672-681; doi:10.3390/md12020672
Communication

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

1
, 1
, 2
, 1
, 1
 and 1,*
1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China 2 East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China
* Author to whom correspondence should be addressed.
Received: 25 November 2013 / Revised: 10 December 2013 / Accepted: 13 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract

Six new tetraprenylated alkaloids, designated as malonganenones L–Q (16), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 16 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 16 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively.
Keywords: gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sun, Z.-H.; Cai, Y.-H.; Fan, C.-Q.; Tang, G.-H.; Luo, H.-B.; Yin, S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Mar. Drugs 2014, 12, 672-681.

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