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Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China
East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China
* Author to whom correspondence should be addressed.
Received: 25 November 2013; in revised form: 10 December 2013 / Accepted: 13 January 2014 / Published: 27 January 2014
Abstract: Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1–6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1–6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively.
Keywords: gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
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Sun, Z.-H.; Cai, Y.-H.; Fan, C.-Q.; Tang, G.-H.; Luo, H.-B.; Yin, S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Mar. Drugs 2014, 12, 672-681.
Sun Z-H, Cai Y-H, Fan C-Q, Tang G-H, Luo H-B, Yin S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Marine Drugs. 2014; 12(2):672-681.
Sun, Zhang-Hua; Cai, Ying-Hong; Fan, Cheng-Qi; Tang, Gui-Hua; Luo, Hai-Bin; Yin, Sheng. 2014. "Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo." Mar. Drugs 12, no. 2: 672-681.