Next Article in Journal
Polyunsaturated Aldehydes from Large Phytoplankton of the Atlantic Ocean Surface (42°N to 33°S)
Next Article in Special Issue
Spongionella Secondary Metabolites Protect Mitochondrial Function in Cortical Neurons against Oxidative Stress
Previous Article in Journal
Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds
Previous Article in Special Issue
Holothurian Fucosylated Chondroitin Sulfate
Mar. Drugs 2014, 12(2), 672-681; doi:10.3390/md12020672
Communication

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

1
, 1
, 2
, 1
, 1
 and 1,*
Received: 25 November 2013 / Revised: 10 December 2013 / Accepted: 13 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [681 KB, uploaded 24 February 2015]   |   Browse Figures
Abstract: Six new tetraprenylated alkaloids, designated as malonganenones L–Q (16), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 16 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 16 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively.
Keywords: gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Sun, Z.-H.; Cai, Y.-H.; Fan, C.-Q.; Tang, G.-H.; Luo, H.-B.; Yin, S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Mar. Drugs 2014, 12, 672-681.

AMA Style

Sun Z-H, Cai Y-H, Fan C-Q, Tang G-H, Luo H-B, Yin S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Marine Drugs. 2014; 12(2):672-681.

Chicago/Turabian Style

Sun, Zhang-Hua; Cai, Ying-Hong; Fan, Cheng-Qi; Tang, Gui-Hua; Luo, Hai-Bin; Yin, Sheng. 2014. "Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo." Mar. Drugs 12, no. 2: 672-681.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert