Mar. Drugs 2014, 12(2), 672-681; doi:10.3390/md12020672
Communication

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

Received: 25 November 2013; in revised form: 10 December 2013 / Accepted: 13 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Six new tetraprenylated alkaloids, designated as malonganenones L–Q (16), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 16 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 16 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively.
Keywords: gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
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MDPI and ACS Style

Sun, Z.-H.; Cai, Y.-H.; Fan, C.-Q.; Tang, G.-H.; Luo, H.-B.; Yin, S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Mar. Drugs 2014, 12, 672-681.

AMA Style

Sun Z-H, Cai Y-H, Fan C-Q, Tang G-H, Luo H-B, Yin S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Marine Drugs. 2014; 12(2):672-681.

Chicago/Turabian Style

Sun, Zhang-Hua; Cai, Ying-Hong; Fan, Cheng-Qi; Tang, Gui-Hua; Luo, Hai-Bin; Yin, Sheng. 2014. "Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo." Mar. Drugs 12, no. 2: 672-681.

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