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Open AccessCommunication
Mar. Drugs 2014, 12(2), 672-681; doi:10.3390/md12020672

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China
2
East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China
*
Author to whom correspondence should be addressed.
Received: 25 November 2013 / Revised: 10 December 2013 / Accepted: 13 January 2014 / Published: 27 January 2014
(This article belongs to the collection Bioactive Compounds from Marine Invertebrates)
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Abstract

Six new tetraprenylated alkaloids, designated as malonganenones L–Q (16), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 16 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 16 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 µM, respectively.
Keywords: gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
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MDPI and ACS Style

Sun, Z.-H.; Cai, Y.-H.; Fan, C.-Q.; Tang, G.-H.; Luo, H.-B.; Yin, S. Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo. Mar. Drugs 2014, 12, 672-681.

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