Mar. Drugs 2013, 11(8), 2713-2721; doi:10.3390/md11082713
Article

Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233

1,2,* email, 3email, 2email and 4,* email
1 Ocean College, Zhejiang University, Hangzhou 310058, China 2 GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany 3 Center of Analysis and Measurement, Zhejiang University, Hangzhou 310058, China 4 Pharmacy Department, Baotou Medical College, Baotou 014060, China
* Authors to whom correspondence should be addressed.
Received: 16 May 2013; in revised form: 3 July 2013 / Accepted: 10 July 2013 / Published: 2 August 2013
PDF Full-text Download PDF Full-Text [376 KB, uploaded 2 August 2013 13:51 CEST]
Abstract: Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM.
Keywords: sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities

Supplementary Files

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Wu, B.; Wu, X.; Sun, M.; Li, M. Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Mar. Drugs 2013, 11, 2713-2721.

AMA Style

Wu B, Wu X, Sun M, Li M. Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Marine Drugs. 2013; 11(8):2713-2721.

Chicago/Turabian Style

Wu, Bin; Wu, Xiaodan; Sun, Min; Li, Minhui. 2013. "Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233." Mar. Drugs 11, no. 8: 2713-2721.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert