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Mar. Drugs 2013, 11(8), 2713-2721; doi:10.3390/md11082713

Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233

1,2,* , 3
,
2
and
4,*
1
Ocean College, Zhejiang University, Hangzhou 310058, China
2
GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany
3
Center of Analysis and Measurement, Zhejiang University, Hangzhou 310058, China
4
Pharmacy Department, Baotou Medical College, Baotou 014060, China
*
Authors to whom correspondence should be addressed.
Received: 16 May 2013 / Revised: 3 July 2013 / Accepted: 10 July 2013 / Published: 2 August 2013
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Abstract

Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM. View Full-Text
Keywords: sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities
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MDPI and ACS Style

Wu, B.; Wu, X.; Sun, M.; Li, M. Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Mar. Drugs 2013, 11, 2713-2721.

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