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Mar. Drugs 2013, 11(8), 2713-2721; doi:10.3390/md11082713
Article

Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233

1,2,* , 3
, 2
 and 4,*
Received: 16 May 2013; in revised form: 3 July 2013 / Accepted: 10 July 2013 / Published: 2 August 2013
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Abstract: Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM.
Keywords: sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities sesquiterpenes; Pestalotiopsis sp.; abiotic stress; tyrosinase inhibitory activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, B.; Wu, X.; Sun, M.; Li, M. Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Mar. Drugs 2013, 11, 2713-2721.

AMA Style

Wu B, Wu X, Sun M, Li M. Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233. Marine Drugs. 2013; 11(8):2713-2721.

Chicago/Turabian Style

Wu, Bin; Wu, Xiaodan; Sun, Min; Li, Minhui. 2013. "Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233." Mar. Drugs 11, no. 8: 2713-2721.



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