Mar. Drugs 2013, 11(7), 2682-2694; doi:10.3390/md11072682
Article

Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans

1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China 2 University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
* Author to whom correspondence should be addressed.
Received: 11 March 2013; in revised form: 29 May 2013 / Accepted: 25 June 2013 / Published: 23 July 2013
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Abstract: Four new quinazolinone alkaloids, namely, aniquinazolines A–D (14), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
Keywords: mangrove; endophytic fungus; Aspergillus nidulans; secondary metabolites; bioactivity

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MDPI and ACS Style

An, C.-Y.; Li, X.-M.; Li, C.-S.; Wang, M.-H.; Xu, G.-M.; Wang, B.-G. Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans. Mar. Drugs 2013, 11, 2682-2694.

AMA Style

An C-Y, Li X-M, Li C-S, Wang M-H, Xu G-M, Wang B-G. Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans. Marine Drugs. 2013; 11(7):2682-2694.

Chicago/Turabian Style

An, Chun-Yan; Li, Xiao-Ming; Li, Chun-Shun; Wang, Ming-Hui; Xu, Gang-Ming; Wang, Bin-Gui. 2013. "Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans." Mar. Drugs 11, no. 7: 2682-2694.

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