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Mar. Drugs 2013, 11(7), 2398-2412; doi:10.3390/md11072398
Article

Domoic Acid Improves the Competitive Ability of Pseudo-nitzschia delicatissima against the Diatom Skeletonema marinoi

1,* , 2
 and 2
Received: 17 May 2013; in revised form: 19 June 2013 / Accepted: 28 June 2013 / Published: 11 July 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Plankton)
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Abstract: Because domoic acid, a neurotoxic secondary metabolite produced by marine diatoms in the genus Pseudo-nitzschia, is hypothesized to be part of a high affinity iron uptake system, we investigated whether domoic acid could improve the competitive ability of Pseudo-nitzschia delicatissima, and whether the availability of iron changed the outcome of competition experiments. We found that domoic acid had a slight negative effect on growth of the diatom Skeletonema marinoi when it was grown in monocultures. However, when S. marinoi was cultured with P. delicatissima the presence of domoic acid resulted in a reduction of S. marinoi cells by up to 38% and an increase in P. delicatissima cell numbers by up to 17% under iron replete conditions. Similar effects were not observed in low iron treatments. Domoic acid was not taken up by P. delicatissima cells. Overall, our results indicate that domoic acid can improve the competitive ability of Pseudo-nitzschia spp. and that iron is likely to be involved. This study provides an unusual example of indirect inhibition of competitor growth mediated by a secondary metabolite.
Keywords: iron; Pseudo-nitzschia; harmful algal bloom; competition; domoic acid; allelopathy iron; Pseudo-nitzschia; harmful algal bloom; competition; domoic acid; allelopathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Prince, E.K.; Irmer, F.; Pohnert, G. Domoic Acid Improves the Competitive Ability of Pseudo-nitzschia delicatissima against the Diatom Skeletonema marinoi. Mar. Drugs 2013, 11, 2398-2412.

AMA Style

Prince EK, Irmer F, Pohnert G. Domoic Acid Improves the Competitive Ability of Pseudo-nitzschia delicatissima against the Diatom Skeletonema marinoi. Marine Drugs. 2013; 11(7):2398-2412.

Chicago/Turabian Style

Prince, Emily K.; Irmer, Friederike; Pohnert, Georg. 2013. "Domoic Acid Improves the Competitive Ability of Pseudo-nitzschia delicatissima against the Diatom Skeletonema marinoi." Mar. Drugs 11, no. 7: 2398-2412.



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