Mar. Drugs 2013, 11(5), 1728-1762; doi:10.3390/md11051728
Article

Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures

1 Institute of Sciences of Food Production, National Research Council, Unit of Lecce (CNR, ISPA), Via Prov.le Lecce-Monteroni, Lecce 73100, Italy 2 CoNISMa, National Interuniversity Consortium on Marine Sciences, Local Unit of Lecce, Via Prov.le Lecce-Monteroni, Lecce 73100, Italy 3 University of Salento, Via Prov.le Lecce-Monteroni, Lecce 73100, Italy These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 March 2013; in revised form: 24 April 2013 / Accepted: 25 April 2013 / Published: 22 May 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Plankton)
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Abstract: On a global scale, jellyfish populations in coastal marine ecosystems exhibit increasing trends of abundance. High-density outbreaks may directly or indirectly affect human economical and recreational activities, as well as public health. As the interest in biology of marine jellyfish grows, a number of jellyfish metabolites with healthy potential, such as anticancer or antioxidant activities, is increasingly reported. In this study, the Mediterranean “fried egg jellyfish” Cotylorhiza tuberculata (Macri, 1778) has been targeted in the search forputative valuable bioactive compounds. A medusa extract was obtained, fractionated, characterized by HPLC, GC-MS and SDS-PAGE and assayed for its biological activity on breast cancer cells (MCF-7) and human epidermal keratinocytes (HEKa). The composition of the jellyfish extract included photosynthetic pigments, valuable ω-3 and ω-6 fatty acids, and polypeptides derived either from jellyfish tissues and their algal symbionts. Extract fractions showed antioxidant activity and the ability to affect cell viability and intercellular communication mediated by gap junctions (GJIC) differentially in MCF-7and HEKa cells. A significantly higher cytotoxicity and GJIC enhancement in MCF-7 compared to HEKa cells was recorded. A putative action mechanism for the anticancer bioactivity through the modulation of GJIC has been hypothesized and its nutraceutical and pharmaceutical potential was discussed.
Keywords: bioactive compounds; jellyfish extracts; zooxanthellae; gap junction intercellular communications; anticancer and antioxidant activity

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MDPI and ACS Style

Leone, A.; Lecci, R.M.; Durante, M.; Piraino, S. Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures. Mar. Drugs 2013, 11, 1728-1762.

AMA Style

Leone A, Lecci RM, Durante M, Piraino S. Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures. Marine Drugs. 2013; 11(5):1728-1762.

Chicago/Turabian Style

Leone, Antonella; Lecci, Raffaella M.; Durante, Miriana; Piraino, Stefano. 2013. "Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures." Mar. Drugs 11, no. 5: 1728-1762.

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