Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Mar. Drugs 2013, 11(5), 1440-1455; doi:10.3390/md11051440
Article

Neuritogenic and Neuroprotective Effects of Polar Steroids from the Far East Starfishes Patiria pectinifera and Distolasterias nipon

1
, 1
, 1
, 2,* , 2
 and 2
Received: 5 March 2013; in revised form: 18 April 2013 / Accepted: 22 April 2013 / Published: 3 May 2013
View Full-Text   |   Download PDF [1137 KB, uploaded 3 May 2013]
Abstract: The neuritogenic and neuroprotective activities of six starfish polar steroids, asterosaponin Р1, (25S)-5α-cholestane-3β,4β,6α,7α,8,15α,16β,26-octaol, and (25S)-5α-cholestane-3β,6α,7α,8,15α,16β,26-heptaol (13) from the starfish Patiria pectinifera and distolasterosides D1–D3 (46) from the starfish Distolasterias nipon were analyzed using the mouse neuroblastoma (NB) C-1300 cell line and an organotypic rat hippocampal slice culture (OHSC). All of these compounds enhanced neurite outgrowth in NB cells. Dose-dependent responses to compounds 13 were observed within the concentration range of 10–100 nM, and dose-dependent responses to glycosides 46 were observed at concentrations of 1–50 nM. All the tested substances exhibited notable synergistic effects with trace amounts of nerve growth factor (NGF, 1 ng/mL) or brain-derived neurotrophic factor (BDNF, 0.1 ng/mL). Using NB cells and OHSCs, it was shown for the first time that starfish steroids 16 act as neuroprotectors against oxygen-glucose deprivation (OGD) by increasing the number of surviving cells. Altogether, these results suggest that neurotrophin-like neuritogenic and neuroprotective activities are most likely common properties of starfish polyhydroxysteroids and the related glycosides, although the magnitude of the effect depended on the particular compound structure.
Keywords: steroid; starfish; neuroblastoma; organotypic hippocampal slice culture; neuritogenesis; oxygen-glucose deprivation steroid; starfish; neuroblastoma; organotypic hippocampal slice culture; neuritogenesis; oxygen-glucose deprivation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Palyanova, N.V.; Pankova, T.M.; Starostina, M.V.; Kicha, A.A.; Ivanchina, N.V.; Stonik, V.A. Neuritogenic and Neuroprotective Effects of Polar Steroids from the Far East Starfishes Patiria pectinifera and Distolasterias nipon. Mar. Drugs 2013, 11, 1440-1455.

AMA Style

Palyanova NV, Pankova TM, Starostina MV, Kicha AA, Ivanchina NV, Stonik VA. Neuritogenic and Neuroprotective Effects of Polar Steroids from the Far East Starfishes Patiria pectinifera and Distolasterias nipon. Marine Drugs. 2013; 11(5):1440-1455.

Chicago/Turabian Style

Palyanova, Natalia V.; Pankova, Tatyana M.; Starostina, Marina V.; Kicha, Alla A.; Ivanchina, Natalia V.; Stonik, Valentin A. 2013. "Neuritogenic and Neuroprotective Effects of Polar Steroids from the Far East Starfishes Patiria pectinifera and Distolasterias nipon." Mar. Drugs 11, no. 5: 1440-1455.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert