Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Mar. Drugs 2013, 11(5), 1456-1476; doi:10.3390/md11051456
Article

Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei

1,†
, 2,†,* , 2
, 2
, 1
 and 2
Received: 11 February 2013; in revised form: 10 April 2013 / Accepted: 23 April 2013 / Published: 6 May 2013
View Full-Text   |   Download PDF [702 KB, updated 13 May 2013; original version uploaded 6 May 2013]
Abstract: Three different fucoidan fractions were isolated and purified from the brown alga, Sargassum mcclurei. The SmF1 and SmF2 fucoidans are sulfated heteropolysaccharides that contain fucose, galactose, mannose, xylose and glucose. The SmF3 fucoidan is highly sulfated (35%) galactofucan, and the main chain of the polysaccharide contains a →3)-α-l-Fucp(2,4SO3)-(1→3)-α-l-Fucp(2,4SO3)-(1→ motif with 1,4-linked 3-sulfated α-l-Fucp inserts and 6-linked galactose on reducing end. Possible branching points include the 1,2,6- or 1,3,6-linked galactose and/or 1,3,4-linked fucose residues that could be glycosylated with terminal β-d-Galp residues or chains of alternating sulfated 1,3-linked α-l-Fucp and 1,4-linked β-d-Galp residues, which have been identified in galactofucans for the first time. Both α-l-Fucp and β-d-Galp residues are sulfated at C-2 and/or C-4 (and some C-6 of β-d-Galp) and potentially the C-3 of terminal β-d-Galp, 1,4-linked β-d-Galp and 1,4-linked α-l-Fucp residues. All fucoidans fractions were less cytotoxic and displayed colony formation inhibition in colon cancer DLD-1 cells. Therefore, these fucoidan fractions are potential antitumor agents.
Keywords: brown alga; Sargassum; fucoidan; oligosaccharides; structure; anticancer activity brown alga; Sargassum; fucoidan; oligosaccharides; structure; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Thinh, P.D.; Menshova, R.V.; Ermakova, S.P.; Anastyuk, S.D.; Ly, B.M.; Zvyagintseva, T.N. Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei. Mar. Drugs 2013, 11, 1456-1476.

AMA Style

Thinh PD, Menshova RV, Ermakova SP, Anastyuk SD, Ly BM, Zvyagintseva TN. Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei. Marine Drugs. 2013; 11(5):1456-1476.

Chicago/Turabian Style

Thinh, Pham D.; Menshova, Roza V.; Ermakova, Svetlana P.; Anastyuk, Stanislav D.; Ly, Bui M.; Zvyagintseva, Tatiana N. 2013. "Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei." Mar. Drugs 11, no. 5: 1456-1476.



Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert