Next Article in Journal
Structural and Immunochemical Studies of the Lipopolysaccharide from the Fish Pathogen, Aeromonas bestiarum Strain K296, Serotype O18
Previous Article in Journal
A Therapeutic Potential for Marine Skeletal Proteins in Bone Regeneration
Mar. Drugs 2013, 11(4), 1221-1234; doi:10.3390/md11041221
Article

Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation

1,* , 2
, 3
, 3
, 3
, 4
, 4
, 4
 and 3
Received: 15 February 2013; in revised form: 28 March 2013 / Accepted: 3 April 2013 / Published: 10 April 2013
View Full-Text   |   Download PDF [178 KB, uploaded 10 April 2013]   |   Browse Figures
Abstract: Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain.
Keywords: Stephanolepis hispidus; fish skin; antinociceptive; peixe-porco; marine products Stephanolepis hispidus; fish skin; antinociceptive; peixe-porco; marine products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Carvalho, V.; Fernandes, L.; Conde, T.; Zamith, H.; Silva, R.; Surrage, A.; Frutuoso, V.; Castro-Faria-Neto, H.; Amendoeira, F. Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation. Mar. Drugs 2013, 11, 1221-1234.

AMA Style

Carvalho V, Fernandes L, Conde T, Zamith H, Silva R, Surrage A, Frutuoso V, Castro-Faria-Neto H, Amendoeira F. Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation. Marine Drugs. 2013; 11(4):1221-1234.

Chicago/Turabian Style

Carvalho, Vinicius; Fernandes, Lohengrin; Conde, Taline; Zamith, Helena; Silva, Ronald; Surrage, Andrea; Frutuoso, Valber; Castro-Faria-Neto, Hugo; Amendoeira, Fabio. 2013. "Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation." Mar. Drugs 11, no. 4: 1221-1234.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert