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Recent Advances in the Discovery and Development of Marine Microbial Natural Products
Mar. Drugs 2013, 11(4), 1152-1161; doi:10.3390/md11041152
Article

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.

1
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2
,
3
,
1
,
2
 and
1,*
1 Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA 2 College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA 3 Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea
* Author to whom correspondence should be addressed.
Received: 25 January 2013 / Revised: 8 March 2013 / Accepted: 11 March 2013 / Published: 3 April 2013
(This article belongs to the Special Issue Marine Secondary Metabolites)
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Abstract

Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing molecules, we identified a marine-derived actinomycete strain (CNJ-878) that exhibited activity with cultured Hepa 1c1c7 cells. Based on this activity, a new macrolide, juvenimicin C (1), as well as 5-O-α-l-rhamnosyltylactone (2), were isolated from the culture broth of a Micromonospora sp. Compound 1 enhanced QR1 enzyme activity and glutathione levels by two-fold with CD values of 10.1 and 27.7 μM, respectively. In addition, glutathione reductase and glutathione peroxidase activities were elevated. This is the first reported member of the macrolide class of antibiotics found to mediate these responses.
Keywords: macrolide; Micromonospora; quinone reductase 1; chemoprevention; actinomycete; marine macrolide; Micromonospora; quinone reductase 1; chemoprevention; actinomycete; marine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Carlson, S.; Marler, L.; Nam, S.-J.; Santarsiero, B.D.; Pezzuto, J.M.; Murphy, B.T. Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.. Mar. Drugs 2013, 11, 1152-1161.

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