Next Article in Journal
Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.
Next Article in Special Issue
Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi
Previous Article in Journal
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells
Previous Article in Special Issue
Recent Advances in the Discovery and Development of Marine Microbial Natural Products
Mar. Drugs 2013, 11(4), 1152-1161; doi:10.3390/md11041152
Article

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.

1
, 2
, 3
, 1
, 2
 and 1,*
Received: 25 January 2013; in revised form: 8 March 2013 / Accepted: 11 March 2013 / Published: 3 April 2013
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [501 KB, uploaded 3 April 2013]   |   Browse Figures
Abstract: Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing molecules, we identified a marine-derived actinomycete strain (CNJ-878) that exhibited activity with cultured Hepa 1c1c7 cells. Based on this activity, a new macrolide, juvenimicin C (1), as well as 5-O-α-l-rhamnosyltylactone (2), were isolated from the culture broth of a Micromonospora sp. Compound 1 enhanced QR1 enzyme activity and glutathione levels by two-fold with CD values of 10.1 and 27.7 μM, respectively. In addition, glutathione reductase and glutathione peroxidase activities were elevated. This is the first reported member of the macrolide class of antibiotics found to mediate these responses.
Keywords: macrolide; Micromonospora; quinone reductase 1; chemoprevention; actinomycete; marine macrolide; Micromonospora; quinone reductase 1; chemoprevention; actinomycete; marine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Carlson, S.; Marler, L.; Nam, S.-J.; Santarsiero, B.D.; Pezzuto, J.M.; Murphy, B.T. Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.. Mar. Drugs 2013, 11, 1152-1161.

AMA Style

Carlson S, Marler L, Nam S-J, Santarsiero BD, Pezzuto JM, Murphy BT. Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.. Marine Drugs. 2013; 11(4):1152-1161.

Chicago/Turabian Style

Carlson, Skylar; Marler, Laura; Nam, Sang-Jip; Santarsiero, Bernard D.; Pezzuto, John M.; Murphy, Brian T. 2013. "Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.." Mar. Drugs 11, no. 4: 1152-1161.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert