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Mar. Drugs 2013, 11(4), 1162-1172; doi:10.3390/md11041162
Article

Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.

1,†
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, 2
, 3
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, 1,*  and 1,*
Received: 28 February 2013; in revised form: 18 March 2013 / Accepted: 23 March 2013 / Published: 3 April 2013
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Abstract: Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 414. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 13 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
Keywords: soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhao, M.; Yin, J.; Jiang, W.; Ma, M.; Lei, X.; Xiang, Z.; Dong, J.; Huang, K.; Yan, P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Mar. Drugs 2013, 11, 1162-1172.

AMA Style

Zhao M, Yin J, Jiang W, Ma M, Lei X, Xiang Z, Dong J, Huang K, Yan P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Marine Drugs. 2013; 11(4):1162-1172.

Chicago/Turabian Style

Zhao, Min; Yin, Jian; Jiang, Wei; Ma, Minshan; Lei, Xinxiang; Xiang, Zheng; Dong, Jianyong; Huang, Kexin; Yan, Pengcheng. 2013. "Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.." Mar. Drugs 11, no. 4: 1162-1172.



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