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Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.
School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China
College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China
Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 February 2013; in revised form: 18 March 2013 / Accepted: 23 March 2013 / Published: 3 April 2013
Abstract: Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4–14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1–3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
Keywords: soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity
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MDPI and ACS Style
Zhao, M.; Yin, J.; Jiang, W.; Ma, M.; Lei, X.; Xiang, Z.; Dong, J.; Huang, K.; Yan, P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Mar. Drugs 2013, 11, 1162-1172.
Zhao M, Yin J, Jiang W, Ma M, Lei X, Xiang Z, Dong J, Huang K, Yan P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Marine Drugs. 2013; 11(4):1162-1172.
Zhao, Min; Yin, Jian; Jiang, Wei; Ma, Minshan; Lei, Xinxiang; Xiang, Zheng; Dong, Jianyong; Huang, Kexin; Yan, Pengcheng. 2013. "Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.." Mar. Drugs 11, no. 4: 1162-1172.