Next Article in Journal
Gene Cloning, Expression and Characterization of a Novel Xylanase from the Marine Bacterium, Glaciecola mesophila KMM241
Previous Article in Journal
Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.
Mar. Drugs 2013, 11(4), 1162-1172; doi:10.3390/md11041162

Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.

1,*  and 1,*
1 School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China 2 College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China 3 Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 February 2013 / Revised: 18 March 2013 / Accepted: 23 March 2013 / Published: 3 April 2013
View Full-Text   |   Download PDF [576 KB, uploaded 24 February 2015]   |   Browse Figures


Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 414. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 13 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
Keywords: soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Zhao, M.; Yin, J.; Jiang, W.; Ma, M.; Lei, X.; Xiang, Z.; Dong, J.; Huang, K.; Yan, P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Mar. Drugs 2013, 11, 1162-1172.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert