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Mar. Drugs 2013, 11(3), 775-787; doi:10.3390/md11030775

Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.

*  and *
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China Present address: Department of Entomology, The Pennsylvania State University, University Park, PA 16803, USA.
* Authors to whom correspondence should be addressed.
Received: 26 November 2012 / Revised: 23 January 2013 / Accepted: 26 February 2013 / Published: 11 March 2013
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Seven new polyoxygenated steroids (17) were isolated together with seven known analogues (814) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity.
Keywords: Sarcophyton sp.; steroid; bioactivity; antibacterial; antifungal Sarcophyton sp.; steroid; bioactivity; antibacterial; antifungal
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Wang, Z.; Tang, H.; Wang, P.; Gong, W.; Xue, M.; Zhang, H.; Liu, T.; Liu, B.; Yi, Y.; Zhang, W. Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.. Mar. Drugs 2013, 11, 775-787.

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