Mar. Drugs 2013, 11(3), 623-642; doi:10.3390/md11030623
Review

Glycosylation of Conotoxins

1email, 1email, 2email, 1email and 1,* email
Received: 14 December 2012; in revised form: 25 January 2013 / Accepted: 6 February 2013 / Published: 1 March 2013
(This article belongs to the Special Issue Marine Glycoconjugates)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite specificity membrane receptors, transporters, and various ion channels in the nervous system. However, these peptides are known to contain a high frequency and variability of post-translational modifications—including sometimes O-glycosylation—which are of importance for biological activity. The potential application of specific conotoxins as neuropharmalogical agents and chemical probes requires a full characterization of the relevant peptides, including the structure of the carbohydrate part. In this review, the currently existing knowledge of O-glycosylation of conotoxins is described.
Keywords: cone snails; glycopeptide; glycosylation; l-galactose; neuropeptide; O-glycan; post-translational modification; venom
PDF Full-text Download PDF Full-Text [1028 KB, uploaded 1 March 2013 11:58 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Gerwig, G.J.; Hocking, H.G.; Stöcklin, R.; Kamerling, J.P.; Boelens, R. Glycosylation of Conotoxins. Mar. Drugs 2013, 11, 623-642.

AMA Style

Gerwig GJ, Hocking HG, Stöcklin R, Kamerling JP, Boelens R. Glycosylation of Conotoxins. Marine Drugs. 2013; 11(3):623-642.

Chicago/Turabian Style

Gerwig, Gerrit J.; Hocking, Henry G.; Stöcklin, Reto; Kamerling, Johannis P.; Boelens, Rolf. 2013. "Glycosylation of Conotoxins." Mar. Drugs 11, no. 3: 623-642.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert