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Mar. Drugs 2013, 11(3), 599-610; doi:10.3390/md11030599
Article

Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum

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1 UMR 7200 CNRS, Therapeutic Innovation Laboratory, Faculty of Pharmacy, University of Strasbourg, 64701 Illkirch, France 2 Department of Material Structure Sciences and Technology, University of Cocody, 01 BP 582, Abidjan, Ivory Coast 3 Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland 4 University of Basel, Petersplatz 1, 4003 Basel, Switzerland 5 CNRS INEE-FRE3484 Marine Mollusks Biology and Associated Ecosystems, University of Caen Basse-Normandie, 14032 Caen Cedex, France
* Author to whom correspondence should be addressed.
Received: 12 December 2012 / Revised: 18 January 2013 / Accepted: 7 February 2013 / Published: 26 February 2013
(This article belongs to the Special Issue Marine Algae)
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Abstract

Organic extracts of 20 species of French seaweed have been screened against Trypanosoma brucei rhodesiense trypomastigotes, the parasite responsible for sleeping sickness. These extracts have previously shown potent antiprotozoal activities in vitro against Plasmodium falciparum and Leishmania donovani. The selectivity of the extracts was also evaluated by testing cytotoxicity on a mammalian L6 cell line. The ethyl acetate extract of the brown seaweed, Bifurcaria bifurcata, showed strong trypanocidal activity with a mild selectivity index (IC50 = 0.53 µg/mL; selectivity index (SI) = 11.6). Bio-guided fractionation led to the isolation of eleganolone, the main diterpenoid isolated from this species. Eleganolone contributes only mildly to the trypanocidal activity of the ethyl acetate extract (IC50 = 45.0 µM, SI = 4.0). However, a selective activity against P. falciparum erythrocytic stages in vitro has been highlighted (IC50 = 7.9 µM, SI = 21.6).
Keywords: eleganolone; linear diterpene; Bifurcaria; Plasmodium falciparum; Trypanosoma eleganolone; linear diterpene; Bifurcaria; Plasmodium falciparum; Trypanosoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gallé, J.-B.; Attioua, B.; Kaiser, M.; Rusig, A.-M.; Lobstein, A.; Vonthron-Sénécheau, C. Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum. Mar. Drugs 2013, 11, 599-610.

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