Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium  Kocuria palustris

doi:10.3390/md11020387

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Mar. Drugs 2013, 11(2), 387-398; doi:10.3390/md11020387

Article

Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris

Jesús Martín¹

, Thiciana da S. Sousa¹

, Gloria Crespo¹

, Sara Palomo¹

, Ignacio González¹

, José R. Tormo¹

, Mercedes de la Cruz¹

, Matthew Anderson^2,†

, Russell T. Hill²

, Francisca Vicente¹

, Olga Genilloud¹

and Fernando Reyes^1,*

+ Authors' affiliations

Received: 11 December 2012 / Revised: 9 January 2013 / Accepted: 21 January 2013 / Published: 4 February 2013

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Abstract: A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey’s analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.

Keywords: marine-derived bacteria; Kocuria palustris; thiazolyl peptides; structure elucidation; antibacterial activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary File 1:
Supplementary Information (PDF, 189 KB)
Supplementary File 2:
3D structure (MOL, 9 KB) Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks.
Supplementary File 3:
MOL-Document (MOL, 10 KB) Display in MOL Viewer

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MDPI and ACS Style

Martín, J.; da S. Sousa, T.; Crespo, G.; Palomo, S.; González, I.; Tormo, J.R.; de la Cruz, M.; Anderson, M.; Hill, R.T.; Vicente, F.; Genilloud, O.; Reyes, F. Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Mar. Drugs 2013, 11, 387-398.

AMA Style

Martín J, da S. Sousa T, Crespo G, Palomo S, González I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F. Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Marine Drugs. 2013; 11(2):387-398.

Chicago/Turabian Style

Martín, Jesús; da S. Sousa, Thiciana; Crespo, Gloria; Palomo, Sara; González, Ignacio; Tormo, José R.; de la Cruz, Mercedes; Anderson, Matthew; Hill, Russell T.; Vicente, Francisca; Genilloud, Olga; Reyes, Fernando. 2013. "Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris." Mar. Drugs 11, no. 2: 387-398.

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