Mar. Drugs 2013, 11(12), 4741-4750; doi:10.3390/md11124741
New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
Bin Yang, Shengrong Liao, Xiuping Lin, Junfeng Wang, Juan Liu, Xuefeng Zhou
, Xianwen Yang and Yonghong Liu *
, Xianwen Yang and Yonghong Liu *
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Author to whom correspondence should be addressed.
Received: 5 September 2013 / Revised: 4 November 2013 / Accepted: 4 November 2013 / Published: 2 December 2013
Abstract
Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively. View Full-TextKeywords:
soft coral; Sinularia sp.; sesquiterpenes; sinularianins; NF-κB
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Yang, B.; Liao, S.; Lin, X.; Wang, J.; Liu, J.; Zhou, X.; Yang, X.; Liu, Y. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.. Mar. Drugs 2013, 11, 4741-4750.
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