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Mar. Drugs 2013, 11(12), 4741-4750; doi:10.3390/md11124741

New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
* Author to whom correspondence should be addressed.
Received: 5 September 2013 / Revised: 4 November 2013 / Accepted: 4 November 2013 / Published: 2 December 2013
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Four new sesquiterpenes, sinularianins C–F (36), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 16 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
Keywords: soft coral; Sinularia sp.; sesquiterpenes; sinularianins; NF-κB soft coral; Sinularia sp.; sesquiterpenes; sinularianins; NF-κB
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, B.; Liao, S.; Lin, X.; Wang, J.; Liu, J.; Zhou, X.; Yang, X.; Liu, Y. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.. Mar. Drugs 2013, 11, 4741-4750.

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