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Mar. Drugs 2013, 11(10), 3735-3741; doi:10.3390/md11103735
Article

Oxygenated Ylangene-Derived Sesquiterpenoids from the Soft Coral Lemnalia philippinensis

1,†
,
2,3,†
,
1
,
1
,
4
 and
1,5,6,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 4 College of pharmacy, China Medical University, Taichung 404, Taiwan 5 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan 6 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 27 August 2013 / Revised: 11 September 2013 / Accepted: 24 September 2013 / Published: 30 September 2013
(This article belongs to the collection Bioactive Compounds from Marine Invertebrates)
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Abstract

Chemical examination of a Taiwanese soft coral Lemnalia philippinensis led to the isolation of three oxygenated ylangene-derived sesquiterpenoids 13, including two new metabolites, philippinlins A and B (1 and 2). The structures of these compounds were elucidated on the basis of detailed spectroscopic data. Compound 1 was shown to exhibit cytotoxicity against HepG2, MDA-MB231 and A549 cancer cell lines.
Keywords: Lemnalia philippinensis; ylangene; philippinlins A and B; cytotoxicity Lemnalia philippinensis; ylangene; philippinlins A and B; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xio, Y.-J.; Su, J.-H.; Chen, B.-W.; Tseng, Y.-J.; Wu, Y.-C.; Sheu, J.-H. Oxygenated Ylangene-Derived Sesquiterpenoids from the Soft Coral Lemnalia philippinensis. Mar. Drugs 2013, 11, 3735-3741.

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