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Mar. Drugs 2013, 11(10), 3735-3741; doi:10.3390/md11103735

Oxygenated Ylangene-Derived Sesquiterpenoids from the Soft Coral Lemnalia philippinensis

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 4 College of pharmacy, China Medical University, Taichung 404, Taiwan 5 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan 6 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 27 August 2013 / Revised: 11 September 2013 / Accepted: 24 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Chemical examination of a Taiwanese soft coral Lemnalia philippinensis led to the isolation of three oxygenated ylangene-derived sesquiterpenoids 13, including two new metabolites, philippinlins A and B (1 and 2). The structures of these compounds were elucidated on the basis of detailed spectroscopic data. Compound 1 was shown to exhibit cytotoxicity against HepG2, MDA-MB231 and A549 cancer cell lines.
Keywords: Lemnalia philippinensis; ylangene; philippinlins A and B; cytotoxicity Lemnalia philippinensis; ylangene; philippinlins A and B; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Xio, Y.-J.; Su, J.-H.; Chen, B.-W.; Tseng, Y.-J.; Wu, Y.-C.; Sheu, J.-H. Oxygenated Ylangene-Derived Sesquiterpenoids from the Soft Coral Lemnalia philippinensis. Mar. Drugs 2013, 11, 3735-3741.

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