• Abstract
• Full-Text PDF [611 KB]
• Full-Text XML
• Article Versions Notes
• Supplement File 1

• Article Statistics
• PubMed/Medline
• Google Scholar
• Order Reprints

• Cite this article
• Export to BibTeX
• Export to EndNote

• [+] on DOAJ
• Tsai, T
• Wu, Y
• Su, J
• Lin, W
• Lin, Y
• [+] on Google Scholar
• Tsai, T
• Wu, Y
• Su, J
• Lin, W
• Lin, Y
• [+] on PubMed
• Tsai, T
• Wu, Y
• Su, J
• Lin, W
• Lin, Y

•  CiteULike
•  Facebook
•  Mendeley
•  Twitter

This article is

• freely available
• re-usable

Mar. Drugs 2013, 11(1), 114-123; doi:10.3390/md11010114

Article

A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados

Tsung-Chang Tsai ^1,† , Yu-Jen Wu ^2,† , Jui-Hsin Su ³ , Wei-Tung Lin ⁴  and Yun-Sheng Lin ^5,*

¹ Department of Superintendent, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan ² Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan ³ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan ⁴ Department of Medical Administration, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan ⁵ Department of Biological Science and Technology, Meiho University, Pingtung 91202, Taiwan ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 27 November 2012; in revised form: 11 December 2012 / Accepted: 24 December 2012 / Published: 10 January 2013

Download PDF Full-Text [611 KB, uploaded 10 January 2013 11:56 CET]

Abstract: A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.

Keywords: spatane diterpenoid; soft coral; Sinularia leptoclados

Supplementary Files

• Supplementary File 1:

  Supporting Information (PDF, 782 KB)

Article Statistics

Cite This Article