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Mar. Drugs 2012, 10(9), 2047-2054;

Clinical Trial: Marine Lipid Suppositories as Laxatives

Department of Pediatric Surgery, Children’s Hospital, Landspitali-University Hospital, 101 Reykjavik, Iceland
School of Health Science, University of Iceland, 101 Reykjavik, Iceland
Department of Internal Medicine, Landspitali-University Hospital, 101 Reykjavík, Iceland
Department of Surgery, Landspitali-University Hospital, 101 Reykjavík, Iceland
Deceased on 27 October 2009.
Author to whom correspondence should be addressed.
Received: 3 August 2012 / Revised: 23 August 2012 / Accepted: 5 September 2012 / Published: 20 September 2012
(This article belongs to the Special Issue Marine Lipids)
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Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials. View Full-Text
Keywords: suppositories; ointment; laxative; omega-3 fatty acid; clinical trial suppositories; ointment; laxative; omega-3 fatty acid; clinical trial

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Ormarsson, O.T.; Geirsson, T.; Bjornsson, E.S.; Jonsson, T.; Moller, P.H.; Loftsson, T.; Stefansson, E. Clinical Trial: Marine Lipid Suppositories as Laxatives. Mar. Drugs 2012, 10, 2047-2054.

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