Mar. Drugs 2012, 10(8), 1873-1882; doi:10.3390/md10081873
Article

Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

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Received: 12 June 2012; in revised form: 2 July 2012 / Accepted: 15 August 2012 / Published: 22 August 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
Keywords: amino acid; dog; glucosamine hydrochloride; metabolomic analyses
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MDPI and ACS Style

Osaki, T.; Azuma, K.; Kurozumi, S.; Takamori, Y.; Tsuka, T.; Imagawa, T.; Okamoto, Y.; Minami, S. Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs. Mar. Drugs 2012, 10, 1873-1882.

AMA Style

Osaki T, Azuma K, Kurozumi S, Takamori Y, Tsuka T, Imagawa T, Okamoto Y, Minami S. Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs. Marine Drugs. 2012; 10(8):1873-1882.

Chicago/Turabian Style

Osaki, Tomohiro; Azuma, Kazuo; Kurozumi, Seiji; Takamori, Yoshimori; Tsuka, Takeshi; Imagawa, Tomohiro; Okamoto, Yoshiharu; Minami, Saburo. 2012. "Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs." Mar. Drugs 10, no. 8: 1873-1882.


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