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Mar. Drugs 2012, 10(7), 1572-1581; doi:10.3390/md10071572

Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Nursing, Meiho University, Pingtung 912, Taiwan
3
Department of Food and Nutrition, Meiho University, Pingtung 912, Taiwan
4
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
5
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
*
Author to whom correspondence should be addressed.
Received: 15 June 2012 / Revised: 6 July 2012 / Accepted: 13 July 2012 / Published: 20 July 2012
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Abstract

Seven new sesquiterpenoids, lochmolins A–G (17), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 14 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.
Keywords: soft coral; Sinularia lochmodes; sesquiterpenes; aromadendrane; germacrane soft coral; Sinularia lochmodes; sesquiterpenes; aromadendrane; germacrane
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tseng, Y.-J.; Shen, K.-P.; Lin, H.-L.; Huang, C.-Y.; Dai, C.-F.; Sheu, J.-H. Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes. Mar. Drugs 2012, 10, 1572-1581.

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